- patients with a history of autoimmune disease or iga deficiency - patients with a history of allergy - multi-organ/system failure - pregnant or breastfeeding at the time of study - cancer, history of heart failure, stroke, bronchial asthma - multi-organ/system failure with indications for dialysis, severe hypoxia, failure with conventional treatment methods, indications for ecmo. - the patient is infected with multidrug-resistant bacteria. - the patient is participating in another study. - time from onset to screening> 21 days

- patients with a history of autoimmune disease or iga deficiency - patients with a history of allergy - multi-organ/system failure - pregnant or breastfeeding at the time of study - cancer, history of heart failure, stroke, bronchial asthma - multi-organ/system failure with indications for dialysis, severe hypoxia, failure with conventional treatment methods, indications for ecmo. - the patient is infected with multidrug-resistant bacteria. - the patient is participating in another study. - time from onset to screening> 21 days