inclusion criteria: - respiratory rate > 30 cycle/minute, bilateral ct infiltration > 30%, pao2/fio2 ratio <150 or saturation <90 on >6l/min, two positive laboratory tests of: (crp>100 g/dl, lymphocytes<600 /mm3, d dimer>l, ferritin >500)

inclusion criteria: - respiratory rate > 30 cycle/minute, bilateral ct infiltration > 30%, pao2/fio2 ratio <150 or saturation <90 on >6l/min, two positive laboratory tests of: (crp>100 g/dl, lymphocytes<600 /mm3, d dimer>l, ferritin >500)