- shock requiring vasoactive agents. - requiring invasive mechanical ventilation. - history of malignant hypertension - use of five or more antihypertensive drugs. - history of heart failure with reduced ejection fraction - history of hospitalization for acute heart failure in past 3 months - history of hospitalization for hemorrhagic stroke in the past 3 months. - history of ckd with an egfr <45 ml/min/1.73m2 - history of copd gold iii/iv - history of end-stage dementia - history of active liver cirrhosis - raas blockers therapy previously stopped > 48h. - anticipated discharge in less than 24 hours. - history of current active cancer receiving chemotherapy - inability to obtain informed consent.

- shock requiring vasoactive agents. - requiring invasive mechanical ventilation. - history of malignant hypertension - use of five or more antihypertensive drugs. - history of heart failure with reduced ejection fraction - history of hospitalization for acute heart failure in past 3 months - history of hospitalization for hemorrhagic stroke in the past 3 months. - history of ckd with an egfr <45 ml/min/1.73m2 - history of copd gold iii/iv - history of end-stage dementia - history of active liver cirrhosis - raas blockers therapy previously stopped > 48h. - anticipated discharge in less than 24 hours. - history of current active cancer receiving chemotherapy - inability to obtain informed consent.