Lead-In PK/PD • Serious adverse events / Adverse events (Dose Limiting Toxicity) Randomized pilot • Time to recovery through Day 28, defined as time to achieve (and maintain through Day 28) a WHO ordinal severity scale score of 1, 2 or 3 with a minimum 1-point improvement from baseline

Lead-In PK/PD • Serious adverse events / Adverse events (Dose Limiting Toxicity) Randomized pilot • Time to recovery through Day 28, defined as time to achieve (and maintain through Day 28) a WHO ordinal severity scale score of 1, 2 or 3 with a minimum 1-point improvement from baseline