Willing and able to provide written informed consent on their own prior to performing study procedures In the U.K., subject assent, or proxy consent as per local site procedures, may also be acceptable if both a clinician and second health professional attest that the subject understands the risks and potential benefits of the study and elects to proceed. Outside the U.K., written informed consent may only be obtained from the subject or legally authorized representative. In the event the subject loses capacity during the study, the subject consents to continued participation, except where this is not clinically indicated. 2.Willing and able to comply with study-related procedures/assessments 3. Age 18 to 80 years old 4. Hospitalized (or documentation of a plan to admit to the hospital if the subject is in an emergency department) and requiring supplemental oxygen to maintain saturation > 90% 5. Confirmed symptomatic COVID-19. If testing results are not immediately available, strong clinical suspicion of COVID-19 can be used for inclusion. Testing should still be done in these subjects. Strong clinical suspicion includes: At least 2 of the following: Fever Cough Fatigue Dyspnea, and At least 1 of the following Radiographic evidence of viral pneumonia Close contact with a patient who has previously tested positive for COVID-19 6. Onset of COVID-19-related symptoms > 2 days and < 10 days prior to hospital admission

Willing and able to provide written informed consent on their own prior to performing study procedures In the U.K., subject assent, or proxy consent as per local site procedures, may also be acceptable if both a clinician and second health professional attest that the subject understands the risks and potential benefits of the study and elects to proceed. Outside the U.K., written informed consent may only be obtained from the subject or legally authorized representative. In the event the subject loses capacity during the study, the subject consents to continued participation, except where this is not clinically indicated. 2.Willing and able to comply with study-related procedures/assessments 3. Age 18 to 80 years old 4. Hospitalized (or documentation of a plan to admit to the hospital if the subject is in an emergency department) and requiring supplemental oxygen to maintain saturation > 90% 5. Confirmed symptomatic COVID-19. If testing results are not immediately available, strong clinical suspicion of COVID-19 can be used for inclusion. Testing should still be done in these subjects. Strong clinical suspicion includes: At least 2 of the following: Fever Cough Fatigue Dyspnea, and At least 1 of the following Radiographic evidence of viral pneumonia Close contact with a patient who has previously tested positive for COVID-19 6. Onset of COVID-19-related symptoms > 2 days and < 10 days prior to hospital admission