patients with history or family history of convulsion, epilepsy, encephalopathy and mental illness; those who are allergic to any of the components of the study vaccine, have had a severe allergic reaction to the vaccine in the past, a history of allergy or asthma; serious adverse events related to vaccination occurred after previous vaccination; 4) positive urine pregnancy test in women during lactation or childbearing age; 5) acute febrile disease, infectious disease, sars history; 6) axillary body temperature > 37.0℃; 7) suffering from serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension and uncontrolled medication (systolic blood pressure ≥180mmhg and/or diastolic blood pressure ≥110mmhg when measured on site); 8) patients with serious chronic diseases that are in the advanced stage and cannot be controlled smoothly, such as diabetes and thyroid diseases; 9) congenital or acquired angioedema/neuroedema; 10) urticaria 1 year before receiving the test vaccine; 11) no spleen or functional no spleen; 12) patients with chronic obstructive pulmonary disease, pulmonary fibrosis and other pulmonary abnormalities; 13) history of novel coronavirus infection/illness; 14) have traveled to medium or high risk areas or left the country in the past 21 days; have a history of novel coronavirus 2019-epidemiological contact; 15) the researcher made a judgment based on various medical, psychological, social or other conditions that might be contrary to the test protocol or affect the subjects to sign informed consent.

patients with history or family history of convulsion, epilepsy, encephalopathy and mental illness; those who are allergic to any of the components of the study vaccine, have had a severe allergic reaction to the vaccine in the past, a history of allergy or asthma; serious adverse events related to vaccination occurred after previous vaccination; 4) positive urine pregnancy test in women during lactation or childbearing age; 5) acute febrile disease, infectious disease, sars history; 6) axillary body temperature > 37.0℃; 7) suffering from serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension and uncontrolled medication (systolic blood pressure ≥180mmhg and/or diastolic blood pressure ≥110mmhg when measured on site); 8) patients with serious chronic diseases that are in the advanced stage and cannot be controlled smoothly, such as diabetes and thyroid diseases; 9) congenital or acquired angioedema/neuroedema; 10) urticaria 1 year before receiving the test vaccine; 11) no spleen or functional no spleen; 12) patients with chronic obstructive pulmonary disease, pulmonary fibrosis and other pulmonary abnormalities; 13) history of novel coronavirus infection/illness; 14) have traveled to medium or high risk areas or left the country in the past 21 days; have a history of novel coronavirus 2019-epidemiological contact; 15) the researcher made a judgment based on various medical, psychological, social or other conditions that might be contrary to the test protocol or affect the subjects to sign informed consent.