a patient whose clinical status is stage 3 or lower on the who 8-point ordinal scale (who 8-os) at the time of randomization an individual who requires endotracheal intubation, mechanical ventilation (who 8-os stage 6), or extracorporeal membrane oxygen therapy (stage 7) at the time of randomization a patient with multiorgan failure, shock, acute respiratory syndrome (ards) a patient with renal dysfunction defined by egfr less than 30ml/min/1.73m², or the use of hemodialysis or hemofiltration cholestatic liver disease (example: biliary obstruction, cholangitis, etc.) or hepatic dysfunction any of the following laboratory test results at the time of screening: an individual with hiv-positive results or who requires antiviral treatments against active hepatitis (hbv, hcv) and etc.

a patient whose clinical status is stage 3 or lower on the who 8-point ordinal scale (who 8-os) at the time of randomization an individual who requires endotracheal intubation, mechanical ventilation (who 8-os stage 6), or extracorporeal membrane oxygen therapy (stage 7) at the time of randomization a patient with multiorgan failure, shock, acute respiratory syndrome (ards) a patient with renal dysfunction defined by egfr less than 30ml/min/1.73m², or the use of hemodialysis or hemofiltration cholestatic liver disease (example: biliary obstruction, cholangitis, etc.) or hepatic dysfunction any of the following laboratory test results at the time of screening: an individual with hiv-positive results or who requires antiviral treatments against active hepatitis (hbv, hcv) and etc.