inclusion criteria: aged 18-90 years pao2/fio2 (pfi) below 200 mmhg (26.7 kpa) suspected or verified sars-cov-2 infection at least two risk factors for increased morbidity/mortality age above 50 years hypertension cardiovascular disease diabetes or pre-diabetes active or cured cancer asthma/copd smoking d-dimer > 1.0 mg/l auto-immune disease documented informed consent according to ich-gcp and national regulations

inclusion criteria: aged 18-90 years pao2/fio2 (pfi) below 200 mmhg (26.7 kpa) suspected or verified sars-cov-2 infection at least two risk factors for increased morbidity/mortality age above 50 years hypertension cardiovascular disease diabetes or pre-diabetes active or cured cancer asthma/copd smoking d-dimer > 1.0 mg/l auto-immune disease documented informed consent according to ich-gcp and national regulations

inclusion criteria: 1. aged 18-90 years 2. pao2/fio2 (pfi) below 200 mmhg (26.7 kpa) 3. suspected or verified sars-cov-2 infection 4. at least two risk factors for increased morbidity/mortality - age above 50 years - hypertension - cardiovascular disease - diabetes or pre-diabetes - active or cured cancer - asthma/copd - smoking - d-dimer > 1.0 mg/l - auto-immune disease 5. documented informed consent according to ich-gcp and national regulations

inclusion criteria: 1. aged 18-90 years 2. pao2/fio2 (pfi) below 200 mmhg (26.7 kpa) 3. suspected or verified sars-cov-2 infection 4. at least two risk factors for increased morbidity/mortality - age above 50 years - hypertension - cardiovascular disease - diabetes or pre-diabetes - active or cured cancer - asthma/copd - smoking - d-dimer > 1.0 mg/l - auto-immune disease 5. documented informed consent according to ich-gcp and national regulations

inclusion criteria: 1. aged 18-90 years 2. pao2/fio2 (pfi) below 200 mmhg (26.7 kpa) 3. suspected or verified sars-cov-2 infection 4. at least two risk factors for increased morbidity/mortality - age above 50 years - hypertension - cardiovascular disease - diabetes or pre-diabetes - active or cured cancer - asthma/copd - smoking - d-dimer > 1.0 - auto-immune disease 5. documented informed consent according to ich-gcp and national regulations

inclusion criteria: 1. aged 18-90 years 2. pao2/fio2 (pfi) below 200 mmhg (26.7 kpa) 3. suspected or verified sars-cov-2 infection 4. at least two risk factors for increased morbidity/mortality - age above 50 years - hypertension - cardiovascular disease - diabetes or pre-diabetes - active or cured cancer - asthma/copd - smoking - d-dimer > 1.0 - auto-immune disease 5. documented informed consent according to ich-gcp and national regulations