Hospitalization for moderate to severe COVID-19, defined as fulfilling at a minimum the following clinical status category on the WHO 8-point ordinal scale (corresponds to RKI score “severe” and “critical”): (i) “score 4” [oxygen via mask or nasal] Bio-ADM ≥50 pg/mL or ≥30% increase until the end of the next day (with a minimum of 35 pg/mL at all) DPP3 ≤ 50 ng/mL Age above 18 years at time of screening Body weight below 150 kg at time of screening

Hospitalization for moderate to severe COVID-19, defined as fulfilling at a minimum the following clinical status category on the WHO 8-point ordinal scale (corresponds to RKI score “severe” and “critical”): (i) “score 4” [oxygen via mask or nasal] Bio-ADM ≥50 pg/mL or ≥30% increase until the end of the next day (with a minimum of 35 pg/mL at all) DPP3 ≤ 50 ng/mL Age above 18 years at time of screening Body weight below 150 kg at time of screening