- age < 18 e > 80 anni - history of bleeding (peptic ulcer, esophageal r, cerebral aneurysm, cancer at high risk of bleeding, cirrhosi, hemorragic stroke < 1 year) - thrombocytopenia (<100 x109/L) - anemia (Hb < 8 g/dl) - coagulation abnormalities (PT and/or aPTT > 1.5, fibrinogen < 150 mg/dl) - consumption coagulopathy (ISTH criteria) - deep venous thrombosis and/or pulmonary embolism - dual antiplatelet therapy - anticoagulant therapy - LMWH allergy - heparin induced thrombocytopenia - major surgery < 1 month, neurosurgery <3 months, eye surgery <3 months - pregnancy - blood arterial hypertension (SBP>160 mm Hg, DBP>100 mm Hg) - renal failure (creatinine clearance < 30 ml/min - ICU admission or endotracheal intubation - PaO2/FiO2 >250 - età < 18 e > 80 anni - emorragia in atto o pregressa (ulcera peptica in trattamento, varici esofagee, aneurismi cerebrali, neoplasia a rischio emorragico, cirrosi epatica, ictus emorragico < 1 anno) - piastrinopenia (<100 x109/L) - anemia (Hb < 8 g/dl) - alterazioni emostasi (PT e/o aPTT > 1.5, fibrinogeno < 150 mg/dl) - coagulopatia da consumo (criteri ISTH) [15, 16] - trombosi venosa profonda e/o embolia polmonare documentata all’ingresso - duplice terapia antiaggregante - terapia anticoagulante in atto - allergia a EBPM - pregressa piastrinopenia da eparina - chirurgia maggiore < 1 mese, neurochirurgia <3 mesi, chirurgia oculistica <3 mesi (esclusa cataratta) - gravidanza - ipertensione arteriosa non controllata (PAS>160 mm Hg, PAD>100 mm Hg) - insufficienza renale definita come clearance creatinina < 30 ml/min - ricovero in rianimazione o intubazione oro-tracheale - PaO2/FiO2 >250

- age < 18 e > 80 anni - history of bleeding (peptic ulcer, esophageal r, cerebral aneurysm, cancer at high risk of bleeding, cirrhosi, hemorragic stroke < 1 year) - thrombocytopenia (<100 x109/L) - anemia (Hb < 8 g/dl) - coagulation abnormalities (PT and/or aPTT > 1.5, fibrinogen < 150 mg/dl) - consumption coagulopathy (ISTH criteria) - deep venous thrombosis and/or pulmonary embolism - dual antiplatelet therapy - anticoagulant therapy - LMWH allergy - heparin induced thrombocytopenia - major surgery < 1 month, neurosurgery <3 months, eye surgery <3 months - pregnancy - blood arterial hypertension (SBP>160 mm Hg, DBP>100 mm Hg) - renal failure (creatinine clearance < 30 ml/min - ICU admission or endotracheal intubation - PaO2/FiO2 >250 - età < 18 e > 80 anni - emorragia in atto o pregressa (ulcera peptica in trattamento, varici esofagee, aneurismi cerebrali, neoplasia a rischio emorragico, cirrosi epatica, ictus emorragico < 1 anno) - piastrinopenia (<100 x109/L) - anemia (Hb < 8 g/dl) - alterazioni emostasi (PT e/o aPTT > 1.5, fibrinogeno < 150 mg/dl) - coagulopatia da consumo (criteri ISTH) [15, 16] - trombosi venosa profonda e/o embolia polmonare documentata all’ingresso - duplice terapia antiaggregante - terapia anticoagulante in atto - allergia a EBPM - pregressa piastrinopenia da eparina - chirurgia maggiore < 1 mese, neurochirurgia <3 mesi, chirurgia oculistica <3 mesi (esclusa cataratta) - gravidanza - ipertensione arteriosa non controllata (PAS>160 mm Hg, PAD>100 mm Hg) - insufficienza renale definita come clearance creatinina < 30 ml/min - ricovero in rianimazione o intubazione oro-tracheale - PaO2/FiO2 >250