All criteria must apply Patients ≥ 18 years of age at the time of inclusion and who are confirmed, suspected or probable cases of covid-19 based on WHO definitions and SpO2 <90% after 3 minutes 10 cm H2O PEEP + 100% O2 and who are treated by a physician who have specifically undergone formal training in pre-hospital INO administration and the present protocol.

All criteria must apply Patients ≥ 18 years of age at the time of inclusion and who are confirmed, suspected or probable cases of covid-19 based on WHO definitions and SpO2 <90% after 3 minutes 10 cm H2O PEEP + 100% O2 and who are treated by a physician who have specifically undergone formal training in pre-hospital INO administration and the present protocol.