- pregnancy, lactation; - known hypersensitivity to colchicine - known hepatic failure - egfr<20 ml/min - clinical estimation that the patient will require mechanical respiratory support in less than 24 hours - any clinical estimation of the attending physician under which the patient shall be excluded - qtc > 450 msec (colchicine is not known to significantly prolong qtc, but may interact with other medications which prolong qtc). - participation in another clinical trial - under colchicine treatment for other indications - patient who is not likely to comply to study procedures

- pregnancy, lactation; - known hypersensitivity to colchicine - known hepatic failure - egfr<20 ml/min - clinical estimation that the patient will require mechanical respiratory support in less than 24 hours - any clinical estimation of the attending physician under which the patient shall be excluded - qtc > 450 msec (colchicine is not known to significantly prolong qtc, but may interact with other medications which prolong qtc). - participation in another clinical trial - under colchicine treatment for other indications - patient who is not likely to comply to study procedures