1. A COVID-19 diagnosis confirmed with a SARS-CoV-2 infection positive polymerase chain reaction (PCR) test within 30 days from screening. 2. Age 18-80 years. 3. Severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. Clinical and Imaging-based evaluation i. Respiratory rate > 23/min and < 30/min ii. SpO2 at room air ≤94% and ≥90% iii. Bilateral pulmonary infiltrates >25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. Evidence of an exacerbated inflammatory process i. LDH ≥300 U/L or what is the upper limit for normal per age ii. CRP ≥25 mg/L iii. Ferritin ≥500 ng/ml iv. Lymphocytes <800 cells/mm3 v. D-dimers ≥500ng/ml 4. Willing and able to sign an informed consent.

1. A COVID-19 diagnosis confirmed with a SARS-CoV-2 infection positive polymerase chain reaction (PCR) test within 30 days from screening. 2. Age 18-80 years. 3. Severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required): a. Clinical and Imaging-based evaluation i. Respiratory rate > 23/min and < 30/min ii. SpO2 at room air ≤94% and ≥90% iii. Bilateral pulmonary infiltrates >25% within 24-48 hours or a severe deterioration compared to imaging at admission. b. Evidence of an exacerbated inflammatory process i. LDH ≥300 U/L or what is the upper limit for normal per age ii. CRP ≥25 mg/L iii. Ferritin ≥500 ng/ml iv. Lymphocytes <800 cells/mm3 v. D-dimers ≥500ng/ml 4. Willing and able to sign an informed consent.