- severe respiratory disease - cardiac insufficiency, - chronic renal failure, - primary hypogammaglobulinemias, - myelodysplastic syndromes, - chronic linfoproliferative syndromes, - monoclonal gammapathies, - known hypersensitibility, - active cancer, - hiv, hbv or hcv infection, - chronic administration of immunosuppressants, - body transplant history, - chronic liver disease, chronic lung disease with oxygen requirement.

- severe respiratory disease - cardiac insufficiency, - chronic renal failure, - primary hypogammaglobulinemias, - myelodysplastic syndromes, - chronic linfoproliferative syndromes, - monoclonal gammapathies, - known hypersensitibility, - active cancer, - hiv, hbv or hcv infection, - chronic administration of immunosuppressants, - body transplant history, - chronic liver disease, chronic lung disease with oxygen requirement.