Adult patients suffering from SARS-CoV-2 induced severe pneumonia admitted to semi-intensive or intensive COVID Units because of the need of ventilation support. Sign of the informed consent, Patients of either sex, aged 18-80 years (inclusive), Patient with a confirmed virological diagnosis of SARS-CoV2 infection by means of real-time Polymerase Chain Reaction, Hospitalization due to clinical and radiological diagnosis of pneumonia, PaO2/FiO2 value between 150-300 with impending necessity of noninvasive positive pressure respiratory support (nCPAP) or ventilator support through nasal pressure support ventilation (nPSV), Systolic artery pressure >90 mmHg without amine support, Modified Early Warning Score (MEWS) score <3, Absence of known active malignancy. Pazienti adulti ricoverati in COVID Unit intensive e semi-intensive a causa della necessità di supporto ventilatorio per polmonite da SARS-CoV-2. Firma del consenso informato, Pazienti di entrambi i generi, di età compresa tra 18 e gli 80 anni (incluse), Pazienti con una diagnosi virologica di infezione da SARS-CoV-2 confermata mediante real time-Polymerase Chain Reaction, Ospedalizzazione per diagnosi clinica e radiologica di polmonite, Valore di PaO2/FiO2 compreso tra 150-300 tale da richiedere ossigenoterapia e indicazione a supporto respiratorio non invasivo tramite CPAP (positive pressure respiratory) o ventilatorio tramite NPSV (nasal pressure support ventilation), Pressione arteriosa sistolica >90 mm Hg in assenza di supporto aminico, Modified Early Warning Score (MEWS) <3, Assenza di neoplasia attive note.

Adult patients suffering from SARS-CoV-2 induced severe pneumonia admitted to semi-intensive or intensive COVID Units because of the need of ventilation support. Sign of the informed consent, Patients of either sex, aged 18-80 years (inclusive), Patient with a confirmed virological diagnosis of SARS-CoV2 infection by means of real-time Polymerase Chain Reaction, Hospitalization due to clinical and radiological diagnosis of pneumonia, PaO2/FiO2 value between 150-300 with impending necessity of noninvasive positive pressure respiratory support (nCPAP) or ventilator support through nasal pressure support ventilation (nPSV), Systolic artery pressure >90 mmHg without amine support, Modified Early Warning Score (MEWS) score <3, Absence of known active malignancy. Pazienti adulti ricoverati in COVID Unit intensive e semi-intensive a causa della necessità di supporto ventilatorio per polmonite da SARS-CoV-2. Firma del consenso informato, Pazienti di entrambi i generi, di età compresa tra 18 e gli 80 anni (incluse), Pazienti con una diagnosi virologica di infezione da SARS-CoV-2 confermata mediante real time-Polymerase Chain Reaction, Ospedalizzazione per diagnosi clinica e radiologica di polmonite, Valore di PaO2/FiO2 compreso tra 150-300 tale da richiedere ossigenoterapia e indicazione a supporto respiratorio non invasivo tramite CPAP (positive pressure respiratory) o ventilatorio tramite NPSV (nasal pressure support ventilation), Pressione arteriosa sistolica >90 mm Hg in assenza di supporto aminico, Modified Early Warning Score (MEWS) <3, Assenza di neoplasia attive note.