The time to clinical improvement, defined as the time from randomization to an improvement of two points or more (from the status at randomization) on a seven-category ordinal scale or live discharge from the hospital, whichever came first: Seven-category ordinal scale („Cao-Scale' in accordance to Cao B et al. NEJM 2020): −1: not hospitalized with resumption of normal activities, −2: not hospitalized, but unable to resume normal activities, −3: hospitalized, not requiring supplemental oxygen, −4: hospitalized, requiring supplemental oxygen, −5: hospitalized, requiring nasal high-flow oxygen therapy, noninvasive mechanical ventilation, or both, −6: hospitalized, requiring ECMO, invasive mechanical ventilation, or both, and −7: death

The time to clinical improvement, defined as the time from randomization to an improvement of two points or more (from the status at randomization) on a seven-category ordinal scale or live discharge from the hospital, whichever came first: Seven-category ordinal scale („Cao-Scale' in accordance to Cao B et al. NEJM 2020): −1: not hospitalized with resumption of normal activities, −2: not hospitalized, but unable to resume normal activities, −3: hospitalized, not requiring supplemental oxygen, −4: hospitalized, requiring supplemental oxygen, −5: hospitalized, requiring nasal high-flow oxygen therapy, noninvasive mechanical ventilation, or both, −6: hospitalized, requiring ECMO, invasive mechanical ventilation, or both, and −7: death