1. Individuals ≥ 18 years with SARS-CoV-2 infection, confirmed by PCR before study enrollment 2. SARS-CoV-2 positive PCR ≤ 3 days old (date of NP swab) 3. Presence of ≥ 1 SARS-CoV-2 typical symptom (fever, cough, shortness of breath, sore throat, headache, fatigue, smell/and or taste disorder, diarrhea, abdominal symptoms, exanthema) and symptom duration ≤ 3 days. 4. Ability to provide written informed consent, or presence of appointed legal guardian or authorized representative who can be informed in the patient's interest and can provided informed consent 5. Presence of at least one of the following criteria: - Patients > 75 years - Patients > 65 years with at least one other risk factor (BMI >35 kg/m2, coronary artery disease, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >35 kg/m2 with at least one other risk factor (CAD, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >40 kg/m2 - Patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary fibrosis - Patients with CKD and a GFR <30 ml/min - Patients with chronic liver disease defined as liver cirrhosis child B or C

1. Individuals ≥ 18 years with SARS-CoV-2 infection, confirmed by PCR before study enrollment 2. SARS-CoV-2 positive PCR ≤ 3 days old (date of NP swab) 3. Presence of ≥ 1 SARS-CoV-2 typical symptom (fever, cough, shortness of breath, sore throat, headache, fatigue, smell/and or taste disorder, diarrhea, abdominal symptoms, exanthema) and symptom duration ≤ 3 days. 4. Ability to provide written informed consent, or presence of appointed legal guardian or authorized representative who can be informed in the patient's interest and can provided informed consent 5. Presence of at least one of the following criteria: - Patients > 75 years - Patients > 65 years with at least one other risk factor (BMI >35 kg/m2, coronary artery disease, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >35 kg/m2 with at least one other risk factor (CAD, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >40 kg/m2 - Patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary fibrosis - Patients with CKD and a GFR <30 ml/min - Patients with chronic liver disease defined as liver cirrhosis child B or C

1. Individuals (female, male diverse) ≥ 18 years with SARS-CoV-2 infection, confirmed by PCR before study enrollment 2. SARS-CoV-2 positive PCR ≤ 3 days old (date of NP swab) 3. Presence of ≥ 1 SARS-CoV-2 typical symptom (fever, cough, shortness of breath, sore throat, headache, fatigue, taste disorder, diarrhea, abdominal symptoms, exanthema) and symptom duration ≤ 3 days. 4. Ability to provide written informed consent 5. Potassium values between 3.5-4.9 mmol/l 6. Platelets on full blood count must be ≥ 50.000/µl 7. Presence of at least one of the following criteria: - Patients > 75 years - Patients > 65 years with at least one other risk factor (BMI >35 kg/m2, coronary artery disease, CKD with GFR <60 ml/min but ≥ 30 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >35 kg/m2 with at least one other risk factor (CAD, CKD with GFR <60 ml/min but ≥ 30 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >40 kg/m2 - Patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary fibrosis

1. Individuals (female, male diverse) ≥ 18 years with SARS-CoV-2 infection, confirmed by PCR before study enrollment 2. SARS-CoV-2 positive PCR ≤ 3 days old (date of NP swab) 3. Presence of ≥ 1 SARS-CoV-2 typical symptom (fever, cough, shortness of breath, sore throat, headache, fatigue, taste disorder, diarrhea, abdominal symptoms, exanthema) and symptom duration ≤ 3 days. 4. Ability to provide written informed consent 5. Potassium values between 3.5-4.9 mmol/l 6. Platelets on full blood count must be ≥ 50.000/µl 7. Presence of at least one of the following criteria: - Patients > 75 years - Patients > 65 years with at least one other risk factor (BMI >35 kg/m2, coronary artery disease, CKD with GFR <60 ml/min but ≥ 30 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >35 kg/m2 with at least one other risk factor (CAD, CKD with GFR <60 ml/min but ≥ 30 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >40 kg/m2 - Patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary fibrosis

1. Individuals ≥ 18 years with SARS-CoV-2 infection, confirmed by PCR before study enrollment 2. SARS-CoV-2 positive PCR ≤ 3 days old (date of NP swab) 3. Presence of ≥ 1 SARS-CoV-2 typical symptom (fever, cough, shortness of breath, sore throat, headache, fatigue, smell/and or taste disorder, diarrhea, abdominal symptoms, exanthema) and symptom duration ≤ 3 days. 4. Ability to provide written informed consent, or presence of appointed legal guardian or authorized representative who can be informed in the patient's interest and can provided informed consent 5. Presence of at least one of the following criteria: - Patients > 75 years - Patients > 65 years with at least one other risk factor (BMI >35 kg/m2, coronary artery disease, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >35 kg/m2 with at least one other risk factor (CAD, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >40 kg/m2 - Patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary fibrosis - Patients with CKD and a GFR <30 ml/min - Patients with chronic liver disease defined as liver cirrhosis child B or C

1. Individuals ≥ 18 years with SARS-CoV-2 infection, confirmed by PCR before study enrollment 2. SARS-CoV-2 positive PCR ≤ 3 days old (date of NP swab) 3. Presence of ≥ 1 SARS-CoV-2 typical symptom (fever, cough, shortness of breath, sore throat, headache, fatigue, smell/and or taste disorder, diarrhea, abdominal symptoms, exanthema) and symptom duration ≤ 3 days. 4. Ability to provide written informed consent, or presence of appointed legal guardian or authorized representative who can be informed in the patient's interest and can provided informed consent 5. Presence of at least one of the following criteria: - Patients > 75 years - Patients > 65 years with at least one other risk factor (BMI >35 kg/m2, coronary artery disease, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >35 kg/m2 with at least one other risk factor (CAD, CKD with GFR <60 ml/min, diabetes mellitus, active tumor disease) - Patients with a BMI >40 kg/m2 - Patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary fibrosis - Patients with CKD and a GFR <30 ml/min - Patients with chronic liver disease defined as liver cirrhosis child B or C