The primary outcome variable will be the number of ventilator-free days defined as the number of days the patient is not receiving mechanical ventilation during the 21 days after randomisation. Mechanical ventilation will be defined as invasive and non-invasive. Patient will be defined free of mechanical ventilation after 12 hours from the suspension of any type of both invasive and non-invasive ventilation.

The primary outcome variable will be the number of ventilator-free days defined as the number of days the patient is not receiving mechanical ventilation during the 21 days after randomisation. Mechanical ventilation will be defined as invasive and non-invasive. Patient will be defined free of mechanical ventilation after 12 hours from the suspension of any type of both invasive and non-invasive ventilation.