1. History of clinically relevant allergies or idiosyncrasies to solnatide. 2. Severe state of septic shock with a Mean Arterial Pressure (MAP) ≤ 65 mm Hg and serum lactate level > 4 mmol/L (36 mg/dL) despite adequate volume resuscitation. 3. An underlying clinical condition that, in the opinion of the Investigator, would make it very unlikely for the patient to be successfully weaned from ventilation due to severe underlying diseases (e.g. severe malnutrition, severe neurological diseases, pulmonary fibrosis or COPD). 4. Extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support. In no way are patients to be denied or delayed these procedures to avoid exclusion from the study. 5. Neutrophil count < 0.3 x 10^9/L. 6. Subjects who are extremely unlikely to survive more than 48 hours due to the acute conditions of the patient in the opinion of the Investigator. 7. Subjects who are not expected to survive the next month because of an underlying uncorrectable medical condition or a do not resuscitate order 8. Women known to be pregnant, lactating or having a positive or indeterminate pregnancy test

1. History of clinically relevant allergies or idiosyncrasies to solnatide. 2. Severe state of septic shock with a Mean Arterial Pressure (MAP) ≤ 65 mm Hg and serum lactate level > 4 mmol/L (36 mg/dL) despite adequate volume resuscitation. 3. An underlying clinical condition that, in the opinion of the Investigator, would make it very unlikely for the patient to be successfully weaned from ventilation due to severe underlying diseases (e.g. severe malnutrition, severe neurological diseases, pulmonary fibrosis or COPD). 4. Extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support. In no way are patients to be denied or delayed these procedures to avoid exclusion from the study. 5. Neutrophil count < 0.3 x 10^9/L. 6. Subjects who are extremely unlikely to survive more than 48 hours due to the acute conditions of the patient in the opinion of the Investigator. 7. Subjects who are not expected to survive the next month because of an underlying uncorrectable medical condition or a do not resuscitate order 8. Women known to be pregnant, lactating or having a positive or indeterminate pregnancy test