Pregnant or breastfeeding woman Known hypersensitivity to chloroquine or hydroxy chloroquine or any excipients Known hypersensitivity to azithromycin, erythromycin or any of the macrolide or ketolide antibiotics or any of the excipients Known deficit in G6PD Known retinopathy Patient with history of cardiac arrythmia related to QT prolongation Suspected acute cardiogenic pulmonary oedema at the time of enrolment QTc >500ms on two consecutive ECG measurements at screening Hypokalaemia (<3.0mmol/L) or hyperkalaemia (>6.1mmol/L) at screening Hypocalcaemia (<2.1mmol/L) or hypercalcaemia (>2.6mmol/L) (corrected for albumin) at screening Subjects receiving medications with a significant QT prolongation potential (if these treatments cannot be discontinued)

Pregnant or breastfeeding woman Known hypersensitivity to chloroquine or hydroxy chloroquine or any excipients Known hypersensitivity to azithromycin, erythromycin or any of the macrolide or ketolide antibiotics or any of the excipients Known deficit in G6PD Known retinopathy Patient with history of cardiac arrythmia related to QT prolongation Suspected acute cardiogenic pulmonary oedema at the time of enrolment QTc >500ms on two consecutive ECG measurements at screening Hypokalaemia (<3.0mmol/L) or hyperkalaemia (>6.1mmol/L) at screening Hypocalcaemia (<2.1mmol/L) or hypercalcaemia (>2.6mmol/L) (corrected for albumin) at screening Subjects receiving medications with a significant QT prolongation potential (if these treatments cannot be discontinued)