1) COVID-19 2) Age ≥18 years 3) Respiratory insufficiency 4) ICU admission COVID-19 will be defined as a positive polymerase chain reaction (PCR) test for SARS-CoV-2, either from a nasal or throat swab or from tracheal suctioning, within the last 14 days prior to ICU admission. Respiratory insufficiency will be defined as a need for supplemental oxygen of at least 10 L/min in patients without a need for mechanical ventilation or invasive or non-invasive mechanical ventilation with a FiO2 ≥ 40%. An ICU will be defined per local practices.

1) COVID-19 2) Age ≥18 years 3) Respiratory insufficiency 4) ICU admission COVID-19 will be defined as a positive polymerase chain reaction (PCR) test for SARS-CoV-2, either from a nasal or throat swab or from tracheal suctioning, within the last 14 days prior to ICU admission. Respiratory insufficiency will be defined as a need for supplemental oxygen of at least 10 L/min in patients without a need for mechanical ventilation or invasive or non-invasive mechanical ventilation with a FiO2 ≥ 40%. An ICU will be defined per local practices.