Written informed consent Age above 18 years Women of childbearing age only: Must agree to practice continuous effective contraception for the duration of the study (a method which results in a failure rate less than 1% per year) Disease severe enough to require hospitalisation QTc interval lower than 450 msec

Written informed consent Age above 18 years Women of childbearing age only: Must agree to practice continuous effective contraception for the duration of the study (a method which results in a failure rate less than 1% per year) Disease severe enough to require hospitalisation QTc interval lower than 450 msec