1. ALT/AST > 5 times the upper limit of normal. 2. Pregnancy or breast feeding. 3. Allergy to any study medication 4. Any medical condition which would impose an unacceptable safety hazard by participation to the study. 5. Study drug specific exclusion criteria: *for Azithromycin : o heart failure with severely reduced ejection fraction (30%) o known prolonged long QT interval on ECG (> 470 msec males and > 480 females with Fridericia criteria, for patients with ventricular conduction delay the use of Rautaharju formula is also allowed ) o patients on Macrolides during the last week before admission *For other treatment strata, see arm-specific protocols.

1. ALT/AST > 5 times the upper limit of normal. 2. Pregnancy or breast feeding. 3. Allergy to any study medication 4. Any medical condition which would impose an unacceptable safety hazard by participation to the study. 5. Study drug specific exclusion criteria: *for Azithromycin : o heart failure with severely reduced ejection fraction (30%) o known prolonged long QT interval on ECG (> 470 msec males and > 480 females with Fridericia criteria, for patients with ventricular conduction delay the use of Rautaharju formula is also allowed ) o patients on Macrolides during the last week before admission *For other treatment strata, see arm-specific protocols.