1. Proof of SARS-CoV2 2. Severe respiratory failure: a. ambient air SpO2 ≤ 92% or b. Need of ≥ 6l O2/min or c. NIV (non-invasive ventilation) or d. IMV (invasive mechanical ventilation) 3. ≥ 18 years 4. Written informed consent obtained from the patient or legal authorized representative or investigator consilium (“Gießener Modell”) according to international guidelines and local laws,

1. Proof of SARS-CoV2 2. Severe respiratory failure: a. ambient air SpO2 ≤ 92% or b. Need of ≥ 6l O2/min or c. NIV (non-invasive ventilation) or d. IMV (invasive mechanical ventilation) 3. ≥ 18 years 4. Written informed consent obtained from the patient or legal authorized representative or investigator consilium (“Gießener Modell”) according to international guidelines and local laws,