Confirmed SARS-CoV2 infection (as defined by positive PCR) Evidence of hyper inflammatory state as evidenced by at least three of the following: o Documented temperature >38°C in the past 48 hours o IL6 >40 pg/ml, or in its absence D-dimer >1.5 μgFEU /ml. o Elevated CRP (>100mg/L) and/or a three-fold increase since presentation o Elevated ferritin X5 ULN o Elevated LDH (above the ULN) o Elevated fibrinogen (above the ULN) Pulmonary infiltrates on chest imaging Moderate to severe respiratory failure as defined by PaO2/FiO2≤300mmHg Aged 18 years or older

Confirmed SARS-CoV2 infection (as defined by positive PCR) Evidence of hyper inflammatory state as evidenced by at least three of the following: o Documented temperature >38°C in the past 48 hours o IL6 >40 pg/ml, or in its absence D-dimer >1.5 μgFEU /ml. o Elevated CRP (>100mg/L) and/or a three-fold increase since presentation o Elevated ferritin X5 ULN o Elevated LDH (above the ULN) o Elevated fibrinogen (above the ULN) Pulmonary infiltrates on chest imaging Moderate to severe respiratory failure as defined by PaO2/FiO2≤300mmHg Aged 18 years or older