Primary or secondary immunodeficiency Use of significant immunosuppressive therapy in the last 3 months (not including hydroxychloroquine or short course of corticosteroids (defined as <400mg cumulative dose) Active malignancy requiring treatment Known active current or history of recurrent bacterial, mycobacterial, fungal or viral infections including history of untreated latent TB History of diverticulitis or chronic ulcerative GI disease that might predispose to GI perforation Severe allergic reaction to monoclonal antibodies Pregnancy or breast feeding AST / ALT with values greater than 10 times normal levels or history of significant liver disease that in the opinion of the investigator precludes use of an investigational agent Neutrophils < 0.5 x109/L Platelets < 50x109/L Documented, uncontrolled sepsis caused by pathogen(s) other than COVID-19 Presence of co-morbidities (including cognitive impairment and/or frailty) that, in the opinion of the investigator, should preclude use of an investigational agent Current skin or soft tissue infection not controlled by antibiotics Body weight ≤ 30kg

Primary or secondary immunodeficiency Use of significant immunosuppressive therapy in the last 3 months (not including hydroxychloroquine or short course of corticosteroids (defined as <400mg cumulative dose) Active malignancy requiring treatment Known active current or history of recurrent bacterial, mycobacterial, fungal or viral infections including history of untreated latent TB History of diverticulitis or chronic ulcerative GI disease that might predispose to GI perforation Severe allergic reaction to monoclonal antibodies Pregnancy or breast feeding AST / ALT with values greater than 10 times normal levels or history of significant liver disease that in the opinion of the investigator precludes use of an investigational agent Neutrophils < 0.5 x109/L Platelets < 50x109/L Documented, uncontrolled sepsis caused by pathogen(s) other than COVID-19 Presence of co-morbidities (including cognitive impairment and/or frailty) that, in the opinion of the investigator, should preclude use of an investigational agent Current skin or soft tissue infection not controlled by antibiotics Body weight ≤ 30kg