Adults aged >= 18 years able to provide a valid informed consent to the study Documented COVID-19 according to local requirements, with pneumonia at imaging (Chest-X ray or CT) High inflammation, one of the following: ¿ CRP > 6 times UNL ¿ D-dimer > 1500 ng/ml PaO2/FiO2 250-400 mmHg Adulti >= 18 anni in grado di fornire un valido consenso alla partecipazione allo studio COVID-19 documentata secondo le line guida locali, con polmonite documentata all’imaging (Rx-torace or TC) Stato infiammatorio, uno fra: ¿ PCR > 6 volte UNL ¿ D-dimero > 1500 ng/ml PaO2/FiO2 >400-250 mmHg

Adults aged >= 18 years able to provide a valid informed consent to the study Documented COVID-19 according to local requirements, with pneumonia at imaging (Chest-X ray or CT) High inflammation, one of the following: ¿ CRP > 6 times UNL ¿ D-dimer > 1500 ng/ml PaO2/FiO2 250-400 mmHg Adulti >= 18 anni in grado di fornire un valido consenso alla partecipazione allo studio COVID-19 documentata secondo le line guida locali, con polmonite documentata all’imaging (Rx-torace or TC) Stato infiammatorio, uno fra: ¿ PCR > 6 volte UNL ¿ D-dimero > 1500 ng/ml PaO2/FiO2 >400-250 mmHg