Time to clinical improvement (defined as the time from randomization to either an improvement of two points on a six-category ordinal scale measured daily till day 28 or discharge from the hospital or death) 1. Death 2. Hospitalized, on invasive mechanical ventilation or ECMO, 3. Hospitalized, on non-invasive ventilation or high flow oxygen devices, 4. Hospitalized, requiring supplemental oxygen 5. Hospitalized, not requiring supplemental oxygen 6. Not hospitalized

Time to clinical improvement (defined as the time from randomization to either an improvement of two points on a six-category ordinal scale measured daily till day 28 or discharge from the hospital or death) 1. Death 2. Hospitalized, on invasive mechanical ventilation or ECMO, 3. Hospitalized, on non-invasive ventilation or high flow oxygen devices, 4. Hospitalized, requiring supplemental oxygen 5. Hospitalized, not requiring supplemental oxygen 6. Not hospitalized