1.Mental inability, reluctance or language difficulties that result in difficulty understanding the meaning of study participation. 2.Known or suspected allergy against Pulmozyme (dornase alfa). 3.Chronic obstructive pulmonary disease stage III-IV or another comparable chronic respiratory disease. 4.Participation in a clinical study with an investigational product during the last 30 days. 5.Previous participation in this study. 6.Pregnancy. Women of childbearing potential must agree to use contraceptives for the duration of the study period. 7.Any condition that, in the opinion of the Investigator, would place the patient at increased risk or preclude the patient’s compliance with the study.

1.Mental inability, reluctance or language difficulties that result in difficulty understanding the meaning of study participation. 2.Known or suspected allergy against Pulmozyme (dornase alfa). 3.Chronic obstructive pulmonary disease stage III-IV or another comparable chronic respiratory disease. 4.Participation in a clinical study with an investigational product during the last 30 days. 5.Previous participation in this study. 6.Pregnancy. Women of childbearing potential must agree to use contraceptives for the duration of the study period. 7.Any condition that, in the opinion of the Investigator, would place the patient at increased risk or preclude the patient’s compliance with the study.