Significant co-morbid illness with treatment escalation limited to CPAP Active bleeding PF ratio < 100 on mechanical ventilation OR noradrenaline requirement > 0.5mcg/kg/min to maintain MAP > 65mmHg (suggests futility) Pregnancy Known allergies to Octaplas or excipients

Significant co-morbid illness with treatment escalation limited to CPAP Active bleeding PF ratio < 100 on mechanical ventilation OR noradrenaline requirement > 0.5mcg/kg/min to maintain MAP > 65mmHg (suggests futility) Pregnancy Known allergies to Octaplas or excipients