multi-organ failure severe ards (requiring ventilator support on presentation in the form of invasive or non-invasive ventilation) septic shock severe liver disease acute kidney injury (where gfr< 15 and plasma-sulfamethoxazoleconcentration cannot be monitored) drug allergy/intolerance to co-trimoxazole / sulphar sensitivity pregnancy already receiving tocilizumab or convalescent therapy

multi-organ failure severe ards (requiring ventilator support on presentation in the form of invasive or non-invasive ventilation) septic shock severe liver disease acute kidney injury (where gfr< 15 and plasma-sulfamethoxazoleconcentration cannot be monitored) drug allergy/intolerance to co-trimoxazole / sulphar sensitivity pregnancy already receiving tocilizumab or convalescent therapy

1. multi-organ failure 2. severe ards (requiring ventilator support on presentation in the form of invasive or non-invasive ventilation) 3. septic shock 4. severe liver disease 5. acute kidney injury (where gfr< 15 and plasma-sulfamethoxazoleconcentration cannot be monitored) 6. drug allergy/intolerance to co-trimoxazole / sulphar sensitivity 7. pregnancy 8. already receiving tocilizumab or convalescent therapy

1. multi-organ failure 2. severe ards (requiring ventilator support on presentation in the form of invasive or non-invasive ventilation) 3. septic shock 4. severe liver disease 5. acute kidney injury (where gfr< 15 and plasma-sulfamethoxazoleconcentration cannot be monitored) 6. drug allergy/intolerance to co-trimoxazole / sulphar sensitivity 7. pregnancy 8. already receiving tocilizumab or convalescent therapy