Time-to-clinical improvement,defined as the time from randomisation to a 2-point improvement on 7-point ordinal scale, or discharge from hospital ordeath (whichever occurs first). A clinically significant difference, defined as a difference of at least a two-point improvement on the WHO ordinal scale.

Time-to-clinical improvement,defined as the time from randomisation to a 2-point improvement on 7-point ordinal scale, or discharge from hospital ordeath (whichever occurs first). A clinically significant difference, defined as a difference of at least a two-point improvement on the WHO ordinal scale.