1.Male or non-pregnant female patients at least 18 years old 2.Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection Confirmed cases: prospective participants who tests positive to a validated specific SARS-CoV-2 nucleic acid test or has the virus identified by electron microscopy or viral culture, as per local trust policy ≤ 5 days before randomization. Probable/Suspected case: prospective participitants who have been in contact with a confirmed case of COVID-19, AND has mild to severe Covid-19 clinical symptoms AND radiographic evidence* of pulmonary infiltrates consistent with Covid-19 disease 3.Moderate to severe COVID-19 requiring hospitalisation defined as: a)Clinical status category 3-5 (inclusive) on the 7-point clinical status category scale as proposed by the World Health Organisation (WHO) master protocol: I.Category 3: hospitalized, no oxygen therapy II.Category 4: hospitalized, oxygen by mask or nasal prongs III.Category 5: hospitalized, non-invasive ventilation or high-flow oxygen *where routinely available, no tests will be requested for research purpose

1.Male or non-pregnant female patients at least 18 years old 2.Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection Confirmed cases: prospective participants who tests positive to a validated specific SARS-CoV-2 nucleic acid test or has the virus identified by electron microscopy or viral culture, as per local trust policy ≤ 5 days before randomization. Probable/Suspected case: prospective participitants who have been in contact with a confirmed case of COVID-19, AND has mild to severe Covid-19 clinical symptoms AND radiographic evidence* of pulmonary infiltrates consistent with Covid-19 disease 3.Moderate to severe COVID-19 requiring hospitalisation defined as: a)Clinical status category 3-5 (inclusive) on the 7-point clinical status category scale as proposed by the World Health Organisation (WHO) master protocol: I.Category 3: hospitalized, no oxygen therapy II.Category 4: hospitalized, oxygen by mask or nasal prongs III.Category 5: hospitalized, non-invasive ventilation or high-flow oxygen *where routinely available, no tests will be requested for research purpose