- Phase 2 Inclusion Criteria: 1. Age 18 to 90. 2. Confirmed COVID-19 diagnosis 3. At least one of the following: 1. Respiratory distress, RR => 30 breaths/min without oxygen, 2. Partial arterial oxygen pressure (PaO2) / Fraction of inspiration O2 (FiO2) >100 <300mmHg (1mmHg = 0.133kPa). 4. Chest imaging confirms lung involvement and inflammation. 5. Inflammatory status as documented by at least one of the following: Lactate dehydrogenase (LDH) > normal range, C-reactive protein (CRP) => 100mg/L or IL-6 => 40pg/mL, serum ferritin => 900ng/mL, XDP >20mcg/mL. - Phase 3 Inclusion Criteria: Same as above, other criteria TBD based on Phase 2 outcomes. - Phase 2 Inclusion Criteria: 1. Age 18 to 90. 2. Confirmed COVID-19 diagnosis 3. At least one of the following: 1. Respiratory distress, RR => 30 breaths/min without oxygen, 2. Partial arterial oxygen pressure (PaO2) / Fraction of inspiration O2 (FiO2) >100 <300mmHg (1mmHg = 0.133kPa). 4. Chest imaging confirms lung involvement and inflammation. 5. Inflammatory status as documented by at least one of the following: Lactate dehydrogenase (LDH) > normal range, C-reactive protein (CRP) => 100mg/L or IL-6 => 40pg/mL, serum ferritin => 900ng/mL, XDP >20mcg/mL. - Phase 3 Inclusion Criteria: Same as above, other criteria TBD based on Phase 2 outcomes.

- Phase 2 Inclusion Criteria: 1. Age 18 to 90. 2. Confirmed COVID-19 diagnosis 3. At least one of the following: 1. Respiratory distress, RR => 30 breaths/min without oxygen, 2. Partial arterial oxygen pressure (PaO2) / Fraction of inspiration O2 (FiO2) >100 <300mmHg (1mmHg = 0.133kPa). 4. Chest imaging confirms lung involvement and inflammation. 5. Inflammatory status as documented by at least one of the following: Lactate dehydrogenase (LDH) > normal range, C-reactive protein (CRP) => 100mg/L or IL-6 => 40pg/mL, serum ferritin => 900ng/mL, XDP >20mcg/mL. - Phase 3 Inclusion Criteria: Same as above, other criteria TBD based on Phase 2 outcomes. - Phase 2 Inclusion Criteria: 1. Age 18 to 90. 2. Confirmed COVID-19 diagnosis 3. At least one of the following: 1. Respiratory distress, RR => 30 breaths/min without oxygen, 2. Partial arterial oxygen pressure (PaO2) / Fraction of inspiration O2 (FiO2) >100 <300mmHg (1mmHg = 0.133kPa). 4. Chest imaging confirms lung involvement and inflammation. 5. Inflammatory status as documented by at least one of the following: Lactate dehydrogenase (LDH) > normal range, C-reactive protein (CRP) => 100mg/L or IL-6 => 40pg/mL, serum ferritin => 900ng/mL, XDP >20mcg/mL. - Phase 3 Inclusion Criteria: Same as above, other criteria TBD based on Phase 2 outcomes.