- Phase 2/3 Exclusion Criteria: 1. Cannot obtain informed consent. 2. Severe hepatic dysfunction (Child Pugh score => C, or AST> 5 times the upper limit), Severe renal dysfunction (estimated glomerular filtration rate <= 30mL / min / 1.73 m2) or receive continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. 3. Patients with hypersensitivity to ibuprofen or to more than one non steroidal anti-inflammatory drug or to more than one medication belonging to the class of sulfonamides (e.g. sulfamethazine, sulfamethoxazole, sulfasalazine, nimesulide or celecoxib, hypersensitivity to sulphanilamide antibiotics alone, e.g. sulfamethoxazole, does not qualify for exclusion) 4. Severe, active bleeding such as hemoptysis, gastrointestinal bleeding, central nervous system bleeding, and nosebleeds within 1 month before enrollment. 5. Pregnant and lactating women and those planning to get pregnant. 6. Participated in other interventional clinical trials with investigational medicinal products, not considered suitable for this study by the researchers. 7. At the time of enrollment, patients not in a clinical condition compatible with the oral administration of the study drug. - Phase 2/3 Exclusion Criteria: 1. Cannot obtain informed consent. 2. Severe hepatic dysfunction (Child Pugh score => C, or AST> 5 times the upper limit), Severe renal dysfunction (estimated glomerular filtration rate <= 30mL / min / 1.73 m2) or receive continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. 3. Patients with hypersensitivity to ibuprofen or to more than one non steroidal anti-inflammatory drug or to more than one medication belonging to the class of sulfonamides (e.g. sulfamethazine, sulfamethoxazole, sulfasalazine, nimesulide or celecoxib, hypersensitivity to sulphanilamide antibiotics alone, e.g. sulfamethoxazole, does not qualify for exclusion) 4. Severe, active bleeding such as hemoptysis, gastrointestinal bleeding, central nervous system bleeding, and nosebleeds within 1 month before enrollment. 5. Pregnant and lactating women and those planning to get pregnant. 6. Participated in other interventional clinical trials with investigational medicinal products, not considered suitable for this study by the researchers. 7. At the time of enrollment, patients not in a clinical condition compatible with the oral administration of the study drug.

- Phase 2/3 Exclusion Criteria: 1. Cannot obtain informed consent. 2. Severe hepatic dysfunction (Child Pugh score => C, or AST> 5 times the upper limit), Severe renal dysfunction (estimated glomerular filtration rate <= 30mL / min / 1.73 m2) or receive continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. 3. Patients with hypersensitivity to ibuprofen or to more than one non steroidal anti-inflammatory drug or to more than one medication belonging to the class of sulfonamides (e.g. sulfamethazine, sulfamethoxazole, sulfasalazine, nimesulide or celecoxib, hypersensitivity to sulphanilamide antibiotics alone, e.g. sulfamethoxazole, does not qualify for exclusion) 4. Severe, active bleeding such as hemoptysis, gastrointestinal bleeding, central nervous system bleeding, and nosebleeds within 1 month before enrollment. 5. Pregnant and lactating women and those planning to get pregnant. 6. Participated in other interventional clinical trials with investigational medicinal products, not considered suitable for this study by the researchers. 7. At the time of enrollment, patients not in a clinical condition compatible with the oral administration of the study drug. - Phase 2/3 Exclusion Criteria: 1. Cannot obtain informed consent. 2. Severe hepatic dysfunction (Child Pugh score => C, or AST> 5 times the upper limit), Severe renal dysfunction (estimated glomerular filtration rate <= 30mL / min / 1.73 m2) or receive continuous renal replacement therapy, hemodialysis, or peritoneal dialysis. 3. Patients with hypersensitivity to ibuprofen or to more than one non steroidal anti-inflammatory drug or to more than one medication belonging to the class of sulfonamides (e.g. sulfamethazine, sulfamethoxazole, sulfasalazine, nimesulide or celecoxib, hypersensitivity to sulphanilamide antibiotics alone, e.g. sulfamethoxazole, does not qualify for exclusion) 4. Severe, active bleeding such as hemoptysis, gastrointestinal bleeding, central nervous system bleeding, and nosebleeds within 1 month before enrollment. 5. Pregnant and lactating women and those planning to get pregnant. 6. Participated in other interventional clinical trials with investigational medicinal products, not considered suitable for this study by the researchers. 7. At the time of enrollment, patients not in a clinical condition compatible with the oral administration of the study drug.