- Male or female≥ 18 years of age - Written informed consent of the patient or a proxy - Ability for participant to comply with the requirements of the study - Hospitalized patient with COVID-19 defined as Positive SARS-CoV2 RT-PCR Or typical COVID-19 Radiographic infiltrates on the CT scan (peripheral ground glass without lung cavitation, lymphadenopathy, or pulmonary nodules) other non COVID-19 diagnosis ruled out. - Patient with respiratory symptoms and requirement of oxygen therapy as defined: Oxygen therapy >= 4L/min to maintain Sp02>92% and respiratory rate >=24/min. Or patients under oxygen >= 1L/min and presenting worsening of oxygen requirement defined by an increase of oxygen therapy >= 2L/min to maintain Sp02>92%. - Inflammatory component C-Reactive Protein ≥ 50mg/L. - Patients within the first 20 days from the onset of the first COVID-19 symptoms - Probabilistic antibiotics therapy according to local practice

- Male or female≥ 18 years of age - Written informed consent of the patient or a proxy - Ability for participant to comply with the requirements of the study - Hospitalized patient with COVID-19 defined as Positive SARS-CoV2 RT-PCR Or typical COVID-19 Radiographic infiltrates on the CT scan (peripheral ground glass without lung cavitation, lymphadenopathy, or pulmonary nodules) other non COVID-19 diagnosis ruled out. - Patient with respiratory symptoms and requirement of oxygen therapy as defined: Oxygen therapy >= 4L/min to maintain Sp02>92% and respiratory rate >=24/min. Or patients under oxygen >= 1L/min and presenting worsening of oxygen requirement defined by an increase of oxygen therapy >= 2L/min to maintain Sp02>92%. - Inflammatory component C-Reactive Protein ≥ 50mg/L. - Patients within the first 20 days from the onset of the first COVID-19 symptoms - Probabilistic antibiotics therapy according to local practice