inclusion criteria: - documented to have an rt-pcr-based diagnosis of sars-cov-2 infection by rt-pcr - moderate-to-severe ards as defined by the berlin criteria: ratio of partial pressure of arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) of 200 mm hg or less assessed with a positive end-expiratory pressure (peep) of >5 cm h2o. - intubated for less than 120 hours - age ≥18 years - ability to provide informed consent or duly appointment health care proxy with the authority to provide informed consent.

inclusion criteria: - documented to have an rt-pcr-based diagnosis of sars-cov-2 infection by rt-pcr - moderate-to-severe ards as defined by the berlin criteria: ratio of partial pressure of arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) of 200 mm hg or less assessed with a positive end-expiratory pressure (peep) of >5 cm h2o. - intubated for less than 120 hours - age ≥18 years - ability to provide informed consent or duly appointment health care proxy with the authority to provide informed consent.