Patients are not eligible for the study if ANY of the following apply: --Procedures under local anaesthesia -Symptomatic COVID-19 infection (by confirmed COVID-19 test or a clinical diagnosis), these patients will be eligible for the RECOVERY trial. -Existing regular preoperative treatment with trial drugs -Known history of adverse reaction/contraindication to trial drugs -Pregnancy (including caesarean section) It is anticipated that very few patients listed for surgery will have symptomatic COVID-19 infection at the time of surgery, and although any such patients will be excluded from this trial, they will be eligible for the parallel RECOVERY trial.

Patients are not eligible for the study if ANY of the following apply: --Procedures under local anaesthesia -Symptomatic COVID-19 infection (by confirmed COVID-19 test or a clinical diagnosis), these patients will be eligible for the RECOVERY trial. -Existing regular preoperative treatment with trial drugs -Known history of adverse reaction/contraindication to trial drugs -Pregnancy (including caesarean section) It is anticipated that very few patients listed for surgery will have symptomatic COVID-19 infection at the time of surgery, and although any such patients will be excluded from this trial, they will be eligible for the parallel RECOVERY trial.