- Age <18 years - Pregnancy or breastfeeding - Ongoing antiviral or antiretroviral treatment or HIV positive - Ongoing anti inflammatory treatment (NSAID, corticosteroids) - Ongoing chloroquine or hydroxychloroquine treatment - Confirmed case of SARS-CoV-2 infection (positive PCR) at day 0 - Positive serology for SARS-CoV-1 infection at day 0 - Impossibility of signing the informed consent form - Rejection of participation - Working less than 5 days a week in the Hospital Clinic of Barcelona. - Any contraindication for hydroxychloroquine treatment (9): o Hydroxychloroquine hypersensitivity or 4-aminoquinoline hypersensitivity o Retinopathy, visual field or visual acuity disturbances o QT prolongation, bradycardia (<50bpm), ventricular tachycardia, other arrhythmia, as determined on day 0 ECG or medical history o Potassium < 3 mEq/L or AST or ALT > 5 upper normal limit, as determined on day 0 blood test o Previous myocardial infarction o Myasthenia gravis o Psoriasis or porphyria o Glomerular clearance < 10ml/min o Previous history of severe hypoglycaemia o Ongoing treatment with: antimalarials, antiarrhythmic, tricyclic antidepressants, natalizumab, quinolones, macrolides, agalsidase alfa and beta. - Edad <18 - Embarazo o lactancia - Tratamiento antiviral o VIH+ - Tratamiento antiinflamatorio - Tratamiento con cloroquina o hidroxicloroquina - Caso confirmado de SARS-CoV-2 por PCR - Serología positiva para SARS-CoV-2 - Imposibilidad de firmar consentimiento informado - Rechazo a participar en el estudio - Trabajar menos de 5 días a la semana en el Hospital Clinic of Barcelona. - Contraindicaciones hidroxicloroquina: o Hipersensibilidad o Retinopatía o alteraciones visuales o QT largo, bradicardia (<50bpm), taquicardia ventricular, otras arrhythmias o Potasio< 3 mEq/L or AST or ALT > 5 o Antecedente de infarto de miocardio o Myasthenia gravis o Psoriasis o porfiria o Filtrado glomerular < 10ml/min o Historia de hipoglicemia severa o Tratamiento con: antimaláricos, antiarrítmicos, antidepresivos triciclicos, natalizumab, quinolonas, macrolidos, agalsidasa alfa y beta.

- Age <18 years - Pregnancy or breastfeeding - Ongoing antiviral or antiretroviral treatment or HIV positive - Ongoing anti inflammatory treatment (NSAID, corticosteroids) - Ongoing chloroquine or hydroxychloroquine treatment - Confirmed case of SARS-CoV-2 infection (positive PCR) at day 0 - Positive serology for SARS-CoV-1 infection at day 0 - Impossibility of signing the informed consent form - Rejection of participation - Working less than 5 days a week in the Hospital Clinic of Barcelona. - Any contraindication for hydroxychloroquine treatment (9): o Hydroxychloroquine hypersensitivity or 4-aminoquinoline hypersensitivity o Retinopathy, visual field or visual acuity disturbances o QT prolongation, bradycardia (<50bpm), ventricular tachycardia, other arrhythmia, as determined on day 0 ECG or medical history o Potassium < 3 mEq/L or AST or ALT > 5 upper normal limit, as determined on day 0 blood test o Previous myocardial infarction o Myasthenia gravis o Psoriasis or porphyria o Glomerular clearance < 10ml/min o Previous history of severe hypoglycaemia o Ongoing treatment with: antimalarials, antiarrhythmic, tricyclic antidepressants, natalizumab, quinolones, macrolides, agalsidase alfa and beta. - Edad <18 - Embarazo o lactancia - Tratamiento antiviral o VIH+ - Tratamiento antiinflamatorio - Tratamiento con cloroquina o hidroxicloroquina - Caso confirmado de SARS-CoV-2 por PCR - Serología positiva para SARS-CoV-2 - Imposibilidad de firmar consentimiento informado - Rechazo a participar en el estudio - Trabajar menos de 5 días a la semana en el Hospital Clinic of Barcelona. - Contraindicaciones hidroxicloroquina: o Hipersensibilidad o Retinopatía o alteraciones visuales o QT largo, bradicardia (<50bpm), taquicardia ventricular, otras arrhythmias o Potasio< 3 mEq/L or AST or ALT > 5 o Antecedente de infarto de miocardio o Myasthenia gravis o Psoriasis o porfiria o Filtrado glomerular < 10ml/min o Historia de hipoglicemia severa o Tratamiento con: antimaláricos, antiarrítmicos, antidepresivos triciclicos, natalizumab, quinolonas, macrolidos, agalsidasa alfa y beta.