the following aes associated with any vaccine, or identified on or before the day of vaccination constitute absolute contraindications to further administration of an imp to the volunteer in question. if any of these events occur during the study, the subject will not be eligible to receive a booster dose and will be followed up by the clinical team or their gp until resolution or stabilisation of the event: - anaphylactic reaction following administration of vaccine - pregnancy. an exception to this will be prior to receipt of a booster dose at extra visit b. if a pregnant woman has discussed vaccination with their usual clinician (e.g. gp) and chooses to receive a covid-19 vaccination, this may be administered by the trial team as part of extra visit b or as part of the provision of treatment to controls - any ae that in the opinion of the investigator may affect the safety of the participant or the interpretation of the study results

the following aes associated with any vaccine, or identified on or before the day of vaccination constitute absolute contraindications to further administration of an imp to the volunteer in question. if any of these events occur during the study, the subject will not be eligible to receive a booster dose and will be followed up by the clinical team or their gp until resolution or stabilisation of the event: - anaphylactic reaction following administration of vaccine - pregnancy. an exception to this will be prior to receipt of a booster dose at extra visit b. if a pregnant woman has discussed vaccination with their usual clinician (e.g. gp) and chooses to receive a covid-19 vaccination, this may be administered by the trial team as part of extra visit b or as part of the provision of treatment to controls - any ae that in the opinion of the investigator may affect the safety of the participant or the interpretation of the study results

the following aes associated with any vaccine, or identified on or before the day of vaccination constitute absolute contraindications to further administration of an imp to the volunteer in question. if any of these events occur during the study, the subject will not be eligible to receive a booster dose and will be followed up by the clinical team or their gp until resolution or stabilisation of the event: - anaphylactic reaction following administration of vaccine - pregnancy - any ae that in the opinion of the investigator may affect the safety of the participant or the interpretation of the study results

the following aes associated with any vaccine, or identified on or before the day of vaccination constitute absolute contraindications to further administration of an imp to the volunteer in question. if any of these events occur during the study, the subject will not be eligible to receive a booster dose and will be followed up by the clinical team or their gp until resolution or stabilisation of the event: - anaphylactic reaction following administration of vaccine - pregnancy - any ae that in the opinion of the investigator may affect the safety of the participant or the interpretation of the study results