- pregnant or lactating women (pregnancy test not required, if doubt patient is excluded) - subjects suffering from known cns diseases - lack of (or inability to provide) informed consent - patient under dialysis - any severe medical condition with a prognosis of < 6 months - patients under warfarin treatment - patients under antiviral treatment - patients under chloroquine phosphate or hydroxychloroquine

- pregnant or lactating women (pregnancy test not required, if doubt patient is excluded) - subjects suffering from known cns diseases - lack of (or inability to provide) informed consent - patient under dialysis - any severe medical condition with a prognosis of < 6 months - patients under warfarin treatment - patients under antiviral treatment - patients under chloroquine phosphate or hydroxychloroquine