inclusion criteria: - must have laboratory confirmed covid-19 and admitted to cairo university isolation hospital. - admitted to acute care facility. - must have severe or immediately life-threatening covid-19: severe disease is defined as: - dyspnea, - respiratory frequency ≥ 30/min, - blood oxygen saturation ≤ 93%, - partial pressure of arterial oxygen to fraction of inspired oxygen ratio <300, and/or - lung infiltrates > 50% within 24 to 48 hours (ct finding) life-threatening disease is defined as: - respiratory failure, - septic shock, and/or - multiple organ dysfunction or failure

inclusion criteria: - must have laboratory confirmed covid-19 and admitted to cairo university isolation hospital. - admitted to acute care facility. - must have severe or immediately life-threatening covid-19: severe disease is defined as: - dyspnea, - respiratory frequency ≥ 30/min, - blood oxygen saturation ≤ 93%, - partial pressure of arterial oxygen to fraction of inspired oxygen ratio <300, and/or - lung infiltrates > 50% within 24 to 48 hours (ct finding) life-threatening disease is defined as: - respiratory failure, - septic shock, and/or - multiple organ dysfunction or failure