inclusion criteria: - provide written informed consent - male or female subjects age >18 years at the time of signing the informed consent form - must have a clinical diagnosis of covid-19, with at least one of clinical symptoms (e.g., fever ≥38°c, fatigue, cough) and a positive result by the reverse-transcription polymerase chain reaction (rt-pcr) testing or equivalent - individuals with moderate to severe covid-19 symptoms - adequate venous access - for female patients only, willingness to use recommended birth control until 6 months post-treatment - must agree to comply with all study requirements and be willing to complete all study visits - need in-patient admission

inclusion criteria: - provide written informed consent - male or female subjects age >18 years at the time of signing the informed consent form - must have a clinical diagnosis of covid-19, with at least one of clinical symptoms (e.g., fever ≥38°c, fatigue, cough) and a positive result by the reverse-transcription polymerase chain reaction (rt-pcr) testing or equivalent - individuals with moderate to severe covid-19 symptoms - adequate venous access - for female patients only, willingness to use recommended birth control until 6 months post-treatment - must agree to comply with all study requirements and be willing to complete all study visits - need in-patient admission