- phase 1 only: patients maintaining o2 saturation >94% on room air - in the opinion of the investigator, unlikely to survive for >48 hours from screening - receiving extracorporeal membrane oxygenation (ecmo) - has new-onset stroke or seizure disorder during hospitalization - initiated on renal replacement therapy due to covid-19 note: other protocol defined inclusion / exclusion criteria apply

- phase 1 only: patients maintaining o2 saturation >94% on room air - in the opinion of the investigator, unlikely to survive for >48 hours from screening - receiving extracorporeal membrane oxygenation (ecmo) - has new-onset stroke or seizure disorder during hospitalization - initiated on renal replacement therapy due to covid-19 note: other protocol defined inclusion / exclusion criteria apply