- patient/ family members who do not give consent to participate in the study. - patients with age less than 18 years - patients presenting with multi-organ failure - pregnancy - individuals with hiv and viral hepatitis and cancer - extremely moribund patients with an expected life expectancy of less than 24 hours - hemodynamic instability requiring vasopressors - previous history of allergy to plasma - cirrhosis - severe renal impairment with gfr< 30ml/min or recipients of rrt, peritoneal dialysis - patients with uncontrolled diabetes mellitus, hypertension, arrhythmias and unstable angina donor inclusion criteria for plasmapheresis - virologically documented (pcr positive by nasopharyngeal swab) who is recovered and free of symptoms for 14 days. - has tested negative for sars cov 2 on two consecutive tests 24 hrs apart. - fulfill all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act 1940 and rules 1945, amended 11.03.2020 - females who have been pregnant may be tested for anti-hla antibodies and eligible if negative for the same. donors

- patient/ family members who do not give consent to participate in the study. - patients with age less than 18 years - patients presenting with multi-organ failure - pregnancy - individuals with hiv and viral hepatitis and cancer - extremely moribund patients with an expected life expectancy of less than 24 hours - hemodynamic instability requiring vasopressors - previous history of allergy to plasma - cirrhosis - severe renal impairment with gfr< 30ml/min or recipients of rrt, peritoneal dialysis - patients with uncontrolled diabetes mellitus, hypertension, arrhythmias and unstable angina donor inclusion criteria for plasmapheresis - virologically documented (pcr positive by nasopharyngeal swab) who is recovered and free of symptoms for 14 days. - has tested negative for sars cov 2 on two consecutive tests 24 hrs apart. - fulfill all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act 1940 and rules 1945, amended 11.03.2020 - females who have been pregnant may be tested for anti-hla antibodies and eligible if negative for the same. donors