inclusion criteria: all patients - patients diagnosed with covid-19 infection by rt-pcr technique - patients ≥ 18 years of age - patients in standard care according to the national guide - onset of symptoms ≤ 14 days - signature of informed consent report patients at high risk of progression, defined by all of the following: - score greater than 9 on the call scale - pao2 / fio2 ≤ 200 (parameters adjusted to the height of bogotá, colombia) - x-ray or ct compatible with pneumonia - hospitalized patients critically ill patients, defined by any of the following: - mechanical ventilation requeriment - patients in intensive care unit or intermediate care unit - ventilatory failure, septic shock, dysfunction or multi-organ failure

inclusion criteria: all patients - patients diagnosed with covid-19 infection by rt-pcr technique - patients ≥ 18 years of age - patients in standard care according to the national guide - onset of symptoms ≤ 14 days - signature of informed consent report patients at high risk of progression, defined by all of the following: - score greater than 9 on the call scale - pao2 / fio2 ≤ 200 (parameters adjusted to the height of bogotá, colombia) - x-ray or ct compatible with pneumonia - hospitalized patients critically ill patients, defined by any of the following: - mechanical ventilation requeriment - patients in intensive care unit or intermediate care unit - ventilatory failure, septic shock, dysfunction or multi-organ failure