- negative rt-pcr result from secretion 48 hours prior to study recruitment - history of allergic reaction to blood or plasma in patients with a known history of iga deficiency - patients participating in other clinical trial - history of allergy to blood products - history of confirmed infection and that required antibiotic or antifungal treatment 30 days prior to recruitment - pregnant women

- negative rt-pcr result from secretion 48 hours prior to study recruitment - history of allergic reaction to blood or plasma in patients with a known history of iga deficiency - patients participating in other clinical trial - history of allergy to blood products - history of confirmed infection and that required antibiotic or antifungal treatment 30 days prior to recruitment - pregnant women