- pregnancy and breastfeeding - hypersensitivity to spironolactone - hypersensitivity to bromhexine - known liver failure - glomerular filtration rate <20 ml/ min - physician judgment that the patient will need mechanical ventilation in 24 hours - other indications for spironolactone - active cancer

- pregnancy and breastfeeding - hypersensitivity to spironolactone - hypersensitivity to bromhexine - known liver failure - glomerular filtration rate <20 ml/ min - physician judgment that the patient will need mechanical ventilation in 24 hours - other indications for spironolactone - active cancer