inclusion criteria: - patients older than 18 year up to 75 year-old maximum - eligible for resuscitation care in uci - with proven infection with covid-19, using at least one positive pharyngeal polymerase chain reaction (pcr) test - covid19 infection pneumonia at - stage 2b: hypoxemic pneumonia (respiratory rate >30/min, sat o2<90 mm hg in ambient air) associated with a marked biological inflammatory syndrome (crp>150mg/l) - or stage 3: ards defined by a mechanically ventilated patient with a pao2/fio2 ratio < 300 for more than 24 hours. - or advanced stage 3: moderate to severe ards (pao2/fio2 < 200 to peep of at least 8 cmh2o) on invasive mechanical ventilation associated with another organ failure or syndrome among : 1) shock with norepinephrine dosage > 3 mg/hour, 2) acute renal oligo-anuric failure or requiring extra-renal lavage, 3) hepatocellular failure or coagulopathy with factor v < 50%, 4) myocarditis causing acute heart failure and/or shock. , 5) hemophagocytic syndrome, 6) hyperferritinemia > 5000 ng/ml

inclusion criteria: - patients older than 18 year up to 75 year-old maximum - eligible for resuscitation care in uci - with proven infection with covid-19, using at least one positive pharyngeal polymerase chain reaction (pcr) test - covid19 infection pneumonia at - stage 2b: hypoxemic pneumonia (respiratory rate >30/min, sat o2<90 mm hg in ambient air) associated with a marked biological inflammatory syndrome (crp>150mg/l) - or stage 3: ards defined by a mechanically ventilated patient with a pao2/fio2 ratio < 300 for more than 24 hours. - or advanced stage 3: moderate to severe ards (pao2/fio2 < 200 to peep of at least 8 cmh2o) on invasive mechanical ventilation associated with another organ failure or syndrome among : 1) shock with norepinephrine dosage > 3 mg/hour, 2) acute renal oligo-anuric failure or requiring extra-renal lavage, 3) hepatocellular failure or coagulopathy with factor v < 50%, 4) myocarditis causing acute heart failure and/or shock. , 5) hemophagocytic syndrome, 6) hyperferritinemia > 5000 ng/ml