- patients younger than 18 or older than 75 year-old, - pregnant or breastfeeding woman - patient for whom measures of therapeutic limitations have been issued (non-admission to intensive care unit) - patients treated with immunosuppressant/immunomodulators (not only the concomitant administration of the following drugs prohibited in the protocol: other jak inhibitors, corticosteroids, il6 inhibitors). - patient already included in another interventional therapeutic trial - use of chronic oral corticosteroids > 10 mg prednisone equivalent per day for non-covid-19 related disease - uncontrolled autoimmune disease - patients with active, suspected or known active systemic bacterial, viral (excluding covid-19) or fungal infections that are not controlled (not only hiv, hbv or hcv infection and untreated bacterial or mycotic infection) - patients with severe pre-existing uncontrolled organ dysfunction (heart, liver or kidney failure) not related to covid-19

- patients younger than 18 or older than 75 year-old, - pregnant or breastfeeding woman - patient for whom measures of therapeutic limitations have been issued (non-admission to intensive care unit) - patients treated with immunosuppressant/immunomodulators (not only the concomitant administration of the following drugs prohibited in the protocol: other jak inhibitors, corticosteroids, il6 inhibitors). - patient already included in another interventional therapeutic trial - use of chronic oral corticosteroids > 10 mg prednisone equivalent per day for non-covid-19 related disease - uncontrolled autoimmune disease - patients with active, suspected or known active systemic bacterial, viral (excluding covid-19) or fungal infections that are not controlled (not only hiv, hbv or hcv infection and untreated bacterial or mycotic infection) - patients with severe pre-existing uncontrolled organ dysfunction (heart, liver or kidney failure) not related to covid-19